Archives of Clinical and Biomedical Research

ISSN

2572-5017

Abstracting and Indexing

Irina Kholodnyuk

Biography

Irina Kholodnyuk published latest article in Virology entitled Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines. This article is available in PubMed with an unique identification number PMID: 28892735 and it is published in 2017. The coauthors of this article are Kholodnyuk I; Rudevica Z; Leonciks A; Ehlin-Henriksson B; Kashuba E.


Research Interest

Biomedical Research


Latest Publication Details

Article Title: Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines.

Co-Author(s): Kholodnyuk I; Rudevica Z; Leonciks A; Ehlin-Henriksson B; Kashuba E

Affiliation(s): A. Kirchenstein Institute of Microbiology and Virology, Riga Stradins University (RSU), 5 Ratsupites str, 1067 Riga, Latvia; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 16 Nobels väg, Box 280, 171 77 Stockholm, Sweden. Electronic address: irina.holodnuka@rsu.lv.

PMID 28892735, Year 2017

Abstract: In immunocompetent individuals, EBV establishes in B cells an asymptomatic lifelong latent infection controlled by the immune system. Chemokine receptors regulate immune system function. CCR1 and CCR2 share protein sequence similarity and exert responses to multiple chemokines. The role of these receptors in B cells is largely unknown. We show that the mRNA and functional protein expression of CCR1 and CCR2 is induced in ex vivo B cells upon EBV infection and in established lymphoblastoid cell lines (LCLs). The CCR1 and CCR2B ORF transcripts were determined in LCLs. In contrast, in both the EBV-negative and EBV-positive Burkitt lymphoma cell lines, neither the CCR1, CCR2A, and CCR2B ORF transcripts nor their corresponding proteins were detected. Our data suggest that CCR1/CCR2B could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.

Journal: Virology


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