Archives of Clinical and Biomedical Research

ISSN

2572-5017

Abstracting and Indexing

Dominik Feuerbach

Biography

Dominik Feuerbach published latest article in Neuroscience letters entitled ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157. This article is available in PubMed with an unique identification number PMID: 28923481 and it is published in 2017. The coauthors of this article are Feuerbach D; Schindler P; Barske C; Joller S; Beng-Louka E; Worringer KA; Kommineni S; Kaykas A; Ho DJ; Ye C; Welzenbach K; Elain G; Klein L; Brzak I; Mir AK; Farady CJ; Aichholz R; Popp S; George N; Neumann U.


Research Interest

Biomedical Research


Latest Publication Details

Article Title: ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157.

Co-Author(s): Feuerbach D; Schindler P; Barske C; Joller S; Beng-Louka E; Worringer KA; Kommineni S; Kaykas A; Ho DJ; Ye C; Welzenbach K; Elain G; Klein L; Brzak I; Mir AK; Farady CJ; Aichholz R; Popp S; George N; Neumann U

Affiliation(s): Neuroscience Research, Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: dominik.feuerbach@novartis.com.

PMID 28923481, Year 2017

Abstract: Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, contributes to microglia maintenance, and its ectodomain is shed from the cell surface. Here, the question was addressed at which position sheddases cleave TREM2 and what are the proteases involved in this process. Using both pharmacological and genetic approaches we report that the main protease contributing to the release of TREM2 ectodomain is ADAM17, (a disintegrin and metalloproteinase domain containing protein, also called TACE, TNF? converting enzyme) while ADAM10 plays a minor role. Complementary biochemical experiments reveal that cleavage occurs between histidine 157 and serine 158. Shedding is not altered for the R47H-mutated TREM2 protein that confers an increased risk for the development of Alzheimers disease. These findings reveal a link between shedding of TREM2 and its regulation during inflammatory conditions or chronic neurodegenerative disease like AD in which activity or expression of sheddases might be altered.

Journal: Neuroscience letters


Related Articles

Research Article Open Access Pages: 167 - 182 UK

Stiffness of Cell Micro-Environment Guides Long Term Cell Growth in Cell Seeded Collagen Microspheres

Mesenchymal stem cells are widely implicated as a cell source for tissue engineering of skeletal tissue in cell-based therapy. Physical and mechanical cues are potent controlling factors in cell differentiation and can be implemented as a guide to study cellular respo...Read More

News & Announcements

Fortune Journals follows COPE Guidelines

COPE