Photodynamic Therapy in Vulvar Dystrophy Treatment

In this article, the authors analyzed and systematized the main aspects of the treatment of vulvar dystrophic diseases (VDD). The traditional methods of treatment of this pathology are surgical intervention and non-surgical methods (high-intensity laser radiation, laser CO2 coagulation, vaporization with radiation intensity of more than 1000 W/cm2 of treatment, chemotherapy and immune-modulatory therapy). Despite the effectiveness of these methods, their main deficiency is the high incidence of local recurrence of the disease (from 17% to 48%). The authors present the PDT method as an alternative, organ-preserving and highly effective therapeutic option. Most studies are devoted to the use of 5-ALA and chlorin-based photosensitizers in the treatment of VDD. The authors studied in detail the world experience of PDT for VDD, analyzed and systematized the results of treatment, advantages and disadvantages of the method.

Author(s): Dunaevskaya V, Tzerkovsky DA